Shijiazhuang Zhongshuo Pharmaceutical Co., Ltd

Zhongshuo Pharm  grade HPMC K100M is a high - viscosity type of hydroxypropyl methylcellulose, primarily employed in the pharmaceutical industry as a hydrophilic gel matrix material for extended - release formulations.

 

Basic Information

 

• Composition: Derived from natural cellulose through chemical modification, it consists of cellulose chains with hydroxypropyl and methyl groups attached.

 

• Appearance: Usually presents as a white or near - white fibrous powder or granules.

 

Properties

 

• Solubility: It is water - soluble, forming a transparent and viscous solution in cold water.

 

• Stability: As a non - ionic cellulose ether, it is highly stable in aqueous solutions, showing good compatibility with other excipients and APIs.

 

• Viscosity: It belongs to the high - viscosity category. Among HPMC products, the higher the viscosity, the thicker the gel layer formed upon contact with water, which can slow down the release rate of water - insoluble drugs.

 

Applications

 

• Extended - release tablets: It is often used as a matrix material in the preparation of hydrophilic gel - type extended - release tablets. By adjusting the proportion of HPMC K100M and the drug, the release rate of the drug can be controlled.

 

• Coating material: Due to its good film - forming properties, the film formed has appropriate strength, is permeable, and is not prone to cracking. It can be used as a gastric - soluble coating material, and is often formulated into a composite with pigments, light - shielding agents, and plasticizers for use.

 

• Capsule shell material: It is used to prepare capsule shells and has advantages over gelatin capsule shells. It can overcome the cross - linking problem of gelatin and is more suitable for hygroscopic or water - sensitive contents, which can effectively extend the shelf life of products